What an MTHFR AA Genotype Call Means
An AA call at rs1801133 is the same variant as 677TT, reported on the other strand. How to verify it in your own data, and what to measure next.
Tag: folate
4 posts
MTHFR rs1801133 (C677T): What the Genotype Means and What to Measure
How to pull rs1801133 out of your own VCF without a strand error, what the C677T variant does to the enzyme, and which blood measurements tell you whether it matters for you.
MTHFR rs1801131 (A1298C): reading it from your own data
What the A1298C variant is, how to pull it correctly out of a VCF or a consumer array file without getting burned by strand, and which blood measurements tell you more than the genotype does.
Does MTHFR C677T Cause Depression?
MTHFR variants are common, their effect on depression risk is small, and the clinically useful signal sits in downstream biochemistry rather than the genotype. How to find your own genotype in a VCF and what to measure instead.